National Institute on Drug Abuse

Glossary
Addiction: a chronic, relapsing disease, characterized by compulsive drug-seeking and drug use and by neurochemical and molecular changes in the brain.

Analog: a chemical compound that is similar to another drug in its effects but differs slightly in its chemical structure.

Benzodiazepines: drugs that relieve anxiety or are prescribed as sedatives; among the most widely prescribed medications, including valium and librium.

Central nervous system (CNS): the brain and spinal cord.

Craving: a powerful, often uncontrollable desire for drugs.

Designer drug: an analog of a restricted drug that has psychoactive properties.

Detoxification: a process of allowing the body to rid itself of a drug while managing the symptoms of withdrawal; often the first step in a drug treatment program.

Dopamine: a neurotransmitter present in regions of the brain that regulate movement, emotion, motivation, and feelings of pleasure.

Narcolepsy: a disorder characterized by uncontrollable attacks of deep sleep.

Physical dependence: an adaptive physiological state that occurs with regular drug use and results in a withdrawal syndrome when drug use stops.

Psychosis: a mental disorder characterized by symptoms such as delusions or hallucinations that indicate an impaired conception of reality.

Rush: a surge of euphoric pleasure that rapidly follows administration of a drug.

Serotonin: a neurotransmitter that has been implicated in states of consciousness, mood, depression, and anxiety.

Tolerance: a condition in which higher doses of a drug are required to produce the same effect as experienced initially; often leads to physical dependence.

Toxic: temporary or permanent drug effects that are detrimental to the functioning of an organ or group of organs.

Withdrawal: a variety of symptoms that occur after use of an addictive drug is reduced or stopped.

References
"Blood Level of Intravenous Drug Users," by R.L. Norton, B.T. Burton, and J. McGirr. Journal of Clinical Toxicology 34(4):425-30, 1996.

Epidemiologic Trends in Drug Abuse: Vol. 1. Highlights and Executive Summary of the Community Epidemiology Work Group, June 1997. NIH Pub. No. 98-4207. National Institute on Drug Abuse, 1997.

Epidemiologic Trends in Drug Abuse: Vol. 1. Highlights and Executive Summary of the Community Epidemiology Work Group, December 1996. NIH Pub. No. 97-4204. National Institute on Drug Abuse, 1997.

"Integrating Treatments for Methamphetamine Abuse: A Psychosocial Perspective," by A. Huber, W. Ling, S. Shoptaw, V. Gulati, P. Brethen, and R. Rawson. Journal of Addictive Diseases, 16(4):41-50, 1997.

"Like Methamphetamine, Ecstacy May Cause Long-Term Brain Damage," by R. Mathias. NIDA Notes 11:7, 1996.

Methamphetamine Abuse (NIDA Capsules). NationalInstitute on Drug Abuse, September 1997.

National Methamphetamine Strategy. U.S. Department of Justice, 1996.

National Survey Results on Drug Use From the Monitoring the Future Study, 1975-1994, Vol. I: Secondary School Students. NIH Pub. No. 93-3498. National Institute on Drug Abuse, 1995.

National Survey Results on Drug Use From the Monitoring the Future Study, 1975-1994, Vol. II: College Students and Young Adults. NIH Pub. No. 96-4027. National Institute on Drug Abuse, 1995.

"NIDA Survey Provides First National Data on Drug Abuse During Pregnancy," by R. Mathias. NIDA Notes 10:6-7, 1995.

"Preliminary Results from the 1996 National Household Survey on Drug Abuse". Substance Abuse and Mental Health Services Administration, 1997.

Year-End Preliminary Estimates from the 1996 Drug Abuse Warning Network. Substance Abuse and Mental Health Services Administration, November 1997.